Sixty years of clinical experience with Nobel Biocare osseointegrated implants

This commemorative volume marks the 60th anniversary of Per-Ingvar Brånemark’s groundbreaking treatment of the first edentulous patient, a milestone that revolutionized dental and orthopedic implantology. Featuring a heartfelt preface by Barbro Brånemark, Per-Ingvar’s wife, and edited by Tomas Albrektsson and Bruno Chrcanovic, the book offers a comprehensive journey through the entire history of osseointegrated implants, from the earliest experimental stages and clinical trials to the latest innovations shaping implant dentistry today.

Co-Editor Tomas Albrektsson, a protégé of Brånemark and one of the most cited researchers in the field, has been a central figure in this evolution for over five decades. Legendary pioneers such as George Zarb, Matts Andersson, John Brunski, and Paulo Maló share their insights and experiences, offering a rich historical perspective on the scientific and clinical breakthroughs that shaped the field. The book also explores the business and economic development of Nobelpharma – later to become Nobel Biocare – and the dental implant industry as a whole. Beyond dentistry, it highlights the application of osseointegration in fields such as craniofacial prosthetics, bone-anchored hearing aids, and orthopedics.

Alongside these foundational voices, a new generation of researchers and clinicians presents forward-looking perspectives that illuminate the future of implant dentistry. From early academic resistance to global clinical success, this volume is both a tribute to a visionary legacy and a guide to the next chapter in biomaterials and implant science. A must-read for clinicians, researchers, and students alike.

Contents

Foreword: Tomas Albrektsson
Preface: Barbro Brånemark
1. Bone Anchorage of Oral Implants: Discovery of a New Treatment Concept
Tomas Albrektsson, Bruno Chrcanovic
2. From Animal Studies to Clinical Trials
Tomas Albrektsson, Bruno Chrcanovic
3. Osseointegration: A Definition Evolving Over Time
Magnus Jacobsson, Tomas Albrektsson, Bruno Chrcanovic
4. The Toronto Global Launch
George Zarb
5. The Development of Nobelpharma and the Brånemark System: 1983–1995
Claes Holmberg, Leif Ek
6. Development of the Osseointegration Ecosystem and Nobel Biocare
Ove Granstrand
7. Bone-Anchored Hearing Aids and Craniofacial Prostheses
Anders Tjellström, Kerstin Bergström, Anne-Marie Riedinger
8. Osseointegration in Orthopedics
Tomas Albrektsson, Lars Carlsson, Magnus Jacobsson
9. Zygomatic Implant Rehabilitation: A Dialog Between the Pioneer and the Futurist
Rubén Davó, Shengchi Fan
10. Anodized Implant Surfaces
Tomas Albrektsson, Young-Taeg Sul
11. All-on-4 and Immediate Loading of Implant-Supported Single Crowns and Small Bridges
Paulo Maló
12. The Procera System
Matts Andersson
13. Long-Term Clinical Documentation of Different Oral Implant Systems: A Systematic Review
Bruno Chrcanovic, Ann Wennerberg, Tomas Albrektsson
14. Implant Prosthodontics
Stefan Holst
15. Drivers of Bone Graft Osseointegration
Philipp S. Lienemann, Santiago Raymond-Llorens, Linh Johansson, Michael Meyer
16. The Foundation for Oral Rehabilitation
Jay P. Malmquist
17. The Ultimate Digital Workflow for Full-Arch Rehabilitation
Alessandro Pozzi
18. Development of Novel Anodized Implant Surfaces: Xeal, TiUltra, and N1
Giacomo Fabbri, Ana Ferro, Miguel de Araújo Nobre
19. From the Ground Up: A Scientific Summary of the N1 System
 Jill Helms, John B. Brunski
20. The N1 System: A Synergistic Approach to Implant Placement and Reconstruction
Oded Bahat
21. Flapless Immediate Implant Placement and Provisionalization (FIIPP 2+): A Novel Validated Strategy for High Esthetic Outcomes in Single-Tooth Replacements
Edith Groenendijk
22. Clinical Case with NobelActive and NobelParallel Implants
Lesley David
23. Digital Approach for Congenitally Missing Lateral Incisors: A Focus on the N1
Alexandra Marques